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Partially successful treatment of a patient with chronic lymphocytic leukemia and Hodgkin's disease: Case report and literature review
Author(s) -
Adiga Giridhar U.,
Abebe Lool,
Wiernik Peter H.
Publication year - 2003
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.10300
Subject(s) - chronic lymphocytic leukemia , medicine , nodular sclerosis , mitoxantrone , vinblastine , disease , cd15 , oncology , leukemia , chemotherapy , lymphoma , hodgkin lymphoma , stem cell , biology , cd34 , genetics
Chronic lymphocytic leukemia (CLL) is rarely associated with Hodgkin's disease (HD). We report a case of nodular sclerosis HD in a patient previously diagnosed with CLL. Reed‐Sternberg cells were CD15 + and CD30 + . He was treated with dose‐escalated CHOP and at relapse, mitoxantrone, vinblastine, and CCNU (MVC) with partial response to the former and complete response to the latter, although the patient died 15 months later. Data from 88 other similar cases published in the English language were analyzed. Based on the histological and clinical features at the time of transformation, these patients were divided into distinct categories for analysis. Prognosis was found to be poorer in patients with continued active CLL when compared with those with CLL in remission at the time of transformation to HD. It is suggested that these two presentations may derive from different pathogenic mechanisms. Am. J. Hematol. 72:267–273, 2003. © 2003 Wiley‐Liss, Inc.