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Familial severe congenital neutropenia associated with infantile osteoporosis: A new entity
Author(s) -
Elhasid R.,
Hofbauer L.C.,
IshShalom S.,
BenArush M.,
Koc O.,
Rowe J.M.,
Etzioni A.
Publication year - 2003
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.10261
Subject(s) - osteoprotegerin , medicine , neutropenia , osteoporosis , congenital neutropenia , activator (genetics) , pediatrics , receptor , chemotherapy
A new entity manifested by severe congenital neutropenia associated with osteoporosis and recurrent bone fracture is described in a family. A possible role for a new recognized cytokine system involved in bone remodeling, the osteoprotegerin/receptor activator of nuclear factor‐κB ligand, is suggested. Am. J. Hematol. 72:34–37, 2003. © 2002 Wiley‐Liss, Inc.