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Occurrence of multiple myeloma in both donor and recipient after bone marrow transplantation
Author(s) -
Kumar Arun,
Styler Michael J.,
Topolsky David L.,
Crilley Pamela A.,
Przybysz Thomas M.,
Gladstone Douglas E.
Publication year - 2002
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.10239
Subject(s) - multiple myeloma , medicine , bone marrow , transplantation , bone marrow transplantation , myeloid leukemia , immunology , pathology
Abstract The transplantation of malignant cells during allogeneic transplant is a rare occurrence. 27 months after donating progenitor cells, a diagnosis of multiple myeloma was made in a 6/6 HLA‐phenotypically matched unrelated donor. The 42‐year‐old recipient transplanted for chronic phase chronic myeloid leukemia developed IgA myeloma 40 months after transplantation. Serum electrophoresis and bone marrow investigations established the diagnosis of IgA K multiple myeloma in both. This case illustrates the natural history and biology of multiple myeloma. Am. J. Hematol. 71:227–228, 2002. © 2002 Wiley‐Liss, Inc.