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Myelodysplastic features in visceral leishmaniasis
Author(s) -
Yaralı Neşe,
Fışgın Tunç,
Duru Feride,
Kara Abdurrahman
Publication year - 2002
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.10200
Subject(s) - pancytopenia , medicine , visceral leishmaniasis , bone marrow , peripheral blood , pathology , myelodysplastic syndromes , hemolysis , multiple myeloma , mononuclear phagocyte system , hyperplasia , leishmaniasis , gastroenterology
We have detected trilineage myelodysplasia in two children recently diagnosed to have visceral leishmaniasis (V.L.), which led us to investigate retrospectively available peripheral blood and bone marrow aspirate smears of 5 children previously diagnosed as V.L. We saw that they also had trilineage myelodysplasia. We postulate that elevated levels of tumor necrosis factor‐α (TNFα) may cause trilineage myelodysplasia in the patients with V.L. This nonclonal myelodysplasia may be responsible for pancytopenia along with hypersplenism, hemolysis and reticuloendothelial hyperplasia causing abnormal retention of iron in V.L. Am. J. Hematol. 71:191–195, 2002. © 2002 Wiley‐Liss, Inc.