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Acute promyelocytic leukemia developing in untreated essential thrombocythemia
Author(s) -
Sato Naoaki,
Furukawa Tatsuo,
Masuko Masayoshi,
Hashimoto Shigeo,
Takahashi Hidenobu,
Baba Miyako,
Inano Koichi,
Suzuki Noriatsu,
Toba Ken,
Fuse Ichiro,
Aizawa Yoshifusa
Publication year - 2002
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.10195
Subject(s) - essential thrombocythemia , acute promyelocytic leukemia , medicine , leukemia , cancer research , platelet , retinoic acid , biology , genetics , gene
We describe a patient with untreated essential thrombocythemia (ET) who developed microgranular variant of acute promyelocytic leukemia, 9 years after the initial diagnosis of ET. He achieved complete remission (CR) but relapsed 11 months later. After achieving the second CR, he received peripheral stem cell transplantation from his HLA complete‐matched sibling. Five months after the transplantation, he relapsed again with meningeal infiltration of leukemic cells. In this paper, we review cases of promyelocytic transformation of myeloproliferative diseases (MPD) other than chronic myeloid leukemia (CML). To our knowledge, this is the first case of promyelocytic transformation of Philadelphia chromosome negative untreated ET, in whom both t(15;17) and PML‐RARα fusion were proven. Am. J. Hematol. 71:114–116, 2002. © 2002 Wiley‐Liss, Inc.