Baseline levels of plasma endothelin‐1 (ET‐1) and changes during transfusion in thalassemic patients | Zendy

Viprakasit Vip | Zendy; Kankirawatana Suthida | Zendy; Akarasereet Pravit | Zendy; Durongpisitkul Kritvikrom | Zendy; Chotewuttakorn Sirikul | Zendy; Tanphaichitr Voravarn S. | Zendy

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Baseline levels of plasma endothelin‐1 (ET‐1) and changes during transfusion in thalassemic patients

Author(s) -

Viprakasit Vip,

Kankirawatana Suthida,

Akarasereet Pravit,

Durongpisitkul Kritvikrom,

Chotewuttakorn Sirikul,

Tanphaichitr Voravarn S.

Publication year - 2002

Publication title -

american journal of hematology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.456

H-Index - 105

eISSN - 1096-8652

pISSN - 0361-8609

DOI - 10.1002/ajh.10129

Subject(s) - medicine , thalassemia , endothelin receptor , gastroenterology , endothelin 1 , sickle cell anemia , plasma levels , blood transfusion , hemoglobinopathy , hemolytic anemia , disease , receptor

We studied levels of plasma endothelin‐1 (ET‐1) in 25 β‐thalassemia/Hb E patients before and after blood transfusion. Baseline ET‐1 levels in these patients were significantly higher than in normal controls (10.17 ± 2.1 pg/mL vs. 8.9 ± 2.0 pg/mL, P < 0.05). After blood transfusion, levels of plasma ET‐1 tend to slightly increase during the first 24 hr but significantly decline at the 7 th day to levels (8.01 ± 1.7 pg/mL) which do not differ from those of controls. This study highlights a different alteration of plasma ET‐1 in patients with β‐thalassemia compared to that of patients with sickle‐cell anemia. Am. J. Hematol. 70:260–262, 2002.© 2002 Wiley‐Liss, Inc.

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