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Baseline levels of plasma endothelin‐1 (ET‐1) and changes during transfusion in thalassemic patients
Author(s) -
Viprakasit Vip,
Kankirawatana Suthida,
Akarasereet Pravit,
Durongpisitkul Kritvikrom,
Chotewuttakorn Sirikul,
Tanphaichitr Voravarn S.
Publication year - 2002
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.10129
Subject(s) - medicine , thalassemia , endothelin receptor , gastroenterology , endothelin 1 , sickle cell anemia , plasma levels , blood transfusion , hemoglobinopathy , hemolytic anemia , disease , receptor
We studied levels of plasma endothelin‐1 (ET‐1) in 25 β‐thalassemia/Hb E patients before and after blood transfusion. Baseline ET‐1 levels in these patients were significantly higher than in normal controls (10.17 ± 2.1 pg/mL vs. 8.9 ± 2.0 pg/mL, P < 0.05). After blood transfusion, levels of plasma ET‐1 tend to slightly increase during the first 24 hr but significantly decline at the 7 th day to levels (8.01 ± 1.7 pg/mL) which do not differ from those of controls. This study highlights a different alteration of plasma ET‐1 in patients with β‐thalassemia compared to that of patients with sickle‐cell anemia. Am. J. Hematol. 70:260–262, 2002.© 2002 Wiley‐Liss, Inc.