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Cytogenetic findings in reactive lymphoid hyperplasia: Significance of non‐clonal t(3;14) and t(3;22)
Author(s) -
Au Wing Y.,
Horsman Douglas E.,
Connors Joseph M.,
Klasa Richard J.,
Gascoyne Randy D.
Publication year - 2002
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.10109
Subject(s) - lymphoma , lymphoid hyperplasia , clone (java method) , chromosomal translocation , pathology , karyotype , cytogenetics , population , immunology , biology , medicine , chromosome , genetics , dna , environmental health , gene
Despite several reports of the molecular detection of recurrent lymphoma translocations in reactive lymph nodes (LN), cytogenetic analysis is seldom performed on such cases. We report the clinical and cytogenetic analysis results on 30 reactive LN. Of these, 17 cases yielded either no growth ( n = 9) or normal metaphases only ( n = 8), and seven of the 17 patients subsequently developed lymphoma. Lymphoma developed in all 10 patients with a clonal karyotype (median of 2.6 months). Three patients (1 HIV‐positive) had non‐clonal t(3;14) or t(3;22). Their lymphadenopathy resolved spontaneously, and none progressed to lymphoma at 4–6 years of follow‐up. Molecular methods detected a small B‐cell clone in one case and an oligoclonal B‐cell population in the other. Cytogenetic analysis may be useful for interpreting cases of lymphoid hyperplasia. A clonal abnormality is highly predictive of concurrent and/or subsequent lymphoma. A lymphoma‐specific but non‐clonal abnormality does not necessarily herald the development of subsequent lymphoma. Am. J. Hematol. 70:133–138, 2002.© 2002 Wiley‐Liss, Inc.