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EBV‐associated lymphoma and chronic inflammatory demyelinating polyneuropathy in an adult without overt immunodeficiency
Author(s) -
Kasamon Yvette L.,
Nguyen Thanh N.,
Chan Jennifer A.,
Nascimento Alessandra F.
Publication year - 2002
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.10079
Subject(s) - medicine , chronic inflammatory demyelinating polyneuropathy , lymphoma , rituximab , polyneuropathy , prednisone , nodular sclerosis , immunodeficiency , malignancy , pathology , immunology , antibody , hodgkin lymphoma , immune system
Epstein‐Barr virus (EBV)‐associated lymphoproliferative disease occurs almost exclusively in immunocompromised states. This type of malignancy nevertheless developed in a woman without overt immunocompromise. She presented with rapidly progressive lower extremity weakness that was consistent with a chronic inflammatory demyelinating polyneuropathy (CIDP). CIDP has been documented in Hodgkin's disease but rarely in non‐Hodgkin's disease. Diagnosis was confirmed by lymph node and sural nerve biopsies and by nerve conduction studies. Prednisone, rituximab, cyclophosphamide, doxorubicin, and etoposide were administered with regression of lymphadenopathy and improvement in neurologic symptoms. EBV‐associated lymphoproliferative disease can thus develop in the absence of overt immunodeficiency and may trigger a demyelinating polyneuropathy. Am. J. Hematol. 69:289–293, 2002. © 2002 Wiley‐Liss, Inc.