Premium
Clinical severe hepatic venoocclusive disease during induction treatment of acute monoblastic leukemia managed with defibrotide
Author(s) -
Bairey Osnat,
Kirgner Ilia,
Yakobi Moshe,
Hamdan Ashraf,
BenAri Ziv,
Shaklai Mati
Publication year - 2002
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.10072
Subject(s) - defibrotide , medicine , hepatic veno occlusive disease , hematopoietic stem cell transplantation , complication , leukemia , transplantation , surgery
Hepatic venoocclusive disease (VOD) is the most common complication of cytoreductive therapy used for stem cell transplantation, but it is rarely encountered during induction treatment of acute leukemia. We describe a patient in whom severe clinical VOD developed shortly after induction treatment for acute monoblastic leukemia. Administration of intravenous defibrotide for 19 days induced complete resolution of the VOD. Further consolidation treatment was resumed including high‐dose cytosine arabinoside without further complications. Am. J. Hematol. 69:281–284, 2002. © 2002 Wiley‐Liss, Inc.