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Reduced vitamin E antioxidant capacity in sickle cell disease is related to transfusion status but not to sickle crisis
Author(s) -
Marwah S.S.,
Blann A.D.,
Rea C.,
Phillips J.D.,
Wright J.,
Bareford D.
Publication year - 2002
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.10033
Subject(s) - antioxidant capacity , vitamin c , antioxidant , medicine , disease , vitamin e , oxidative stress , hemoglobinopathy , sickle cell anemia , vitamin , anemia , physiology , immunology , gastroenterology , biology , biochemistry
In homozygous sickle cell disease (SCD), decreased serum Vitamin E is present. Excessive transfusions may lead to iron overload. We hypothesised a relationship between the two and found that Vitamin E type antioxidant capacity was significantly lower in 30 SCD patients than in 30 age‐ and sex‐matched controls ( P < 0.001). Antioxidant capacity was lower in 10 transfused patients compared with 20 non‐transfused patients ( P < 0.001). Transfusional iron overload in SCD may increase the potential for oxidative damage, and low antioxidant capacity may compound this effect. Am. J. Hematol. 69: 144–146, 2002. © 2002 Wiley‐Liss, Inc.