Reduced vitamin E antioxidant capacity in sickle cell disease is related to transfusion status but not to sickle crisis | Zendy

Marwah S.S. | Zendy; Blann A.D. | Zendy; Rea C. | Zendy; Phillips J.D. | Zendy; Wright J. | Zendy; Bareford D. | Zendy

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Reduced vitamin E antioxidant capacity in sickle cell disease is related to transfusion status but not to sickle crisis

Author(s) -

Marwah S.S.,

Blann A.D.,

Rea C.,

Phillips J.D.,

Wright J.,

Bareford D.

Publication year - 2002

Publication title -

american journal of hematology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.456

H-Index - 105

eISSN - 1096-8652

pISSN - 0361-8609

DOI - 10.1002/ajh.10033

Subject(s) - antioxidant capacity , vitamin c , antioxidant , medicine , disease , vitamin e , oxidative stress , hemoglobinopathy , sickle cell anemia , vitamin , anemia , physiology , immunology , gastroenterology , biology , biochemistry

In homozygous sickle cell disease (SCD), decreased serum Vitamin E is present. Excessive transfusions may lead to iron overload. We hypothesised a relationship between the two and found that Vitamin E type antioxidant capacity was significantly lower in 30 SCD patients than in 30 age‐ and sex‐matched controls ( P < 0.001). Antioxidant capacity was lower in 10 transfused patients compared with 20 non‐transfused patients ( P < 0.001). Transfusional iron overload in SCD may increase the potential for oxidative damage, and low antioxidant capacity may compound this effect. Am. J. Hematol. 69: 144–146, 2002. © 2002 Wiley‐Liss, Inc.

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