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Frequency of anti‐heparin‐platelet factor 4 antibodies in hemodialysis patients and correlation with recurrent vascular access thrombosis
Author(s) -
O'Shea Susan I.,
Sands Jeffrey J.,
Nudo Sybil A.,
Ortel Thomas L.
Publication year - 2002
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.10032
Subject(s) - heparin , medicine , platelet factor 4 , thrombosis , hemodialysis , heparin induced thrombocytopenia , platelet , antibody , immunology , surgery
Heparin‐induced thrombocytopenia (HIT), characterized by the formation of antibodies to a complex of platelet factor 4 (PF4) and heparin, is a well‐recognized risk factor for thromboembolic complications. The frequency of antibody development varies among patient populations. Hemodialysis patients have repeated heparin exposure and should be at risk of developing HIT. This might, contribute to the development of vascular access thrombosis. We prospectively evaluated 88 hemodialysis patients for the presence of anti‐PF4/heparin antibodies. Eighteen patients (20%) had a prior history of 1 or more prior access thrombosis. One patient (1.14%), without a history of graft thrombosis, tested positive for anti‐PF4/heparin antibodies. In our study, the presence of anti‐PF4/heparin antibodies was rare and was not increased in patients with a history of vascular access thrombosis. Am. J. Hematol. 69:72‐73, 2002. © 2002 Wiley‐Liss, Inc.