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Expression and sequence analyses of p33 ING1 gene in myeloid leukemia
Author(s) -
Ito K.,
Kinjo K.,
Nakazato T.,
Ikeda Y.,
Kizaki M.
Publication year - 2002
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.10031
Subject(s) - myeloid , cancer research , gene , myeloid leukemia , biology , tumor suppressor gene , suppressor , leukemia , point mutation , mutation , microbiology and biotechnology , genetics , carcinogenesis
p33 ING1 is a novel candidate tumor suppressor gene which is involved in the regulation of apoptosis. p33 ING1 interacts with p53 signaling pathway and regulates cellular growth. It has reported that the expression of p33 ING1 mRNA was decreased in lymphoid malignancies. We thus investigated the potential involvement of p33 ING1 abnormalities in myeloid leukemias. However, the levels of p33 ING1 transcript were almost equal in 3 AML cell lines and 10 fresh AML samples. In addition, neither point mutations nor deletions in p33 ING1 gene were found in myeloid leukemias. These results suggest that p33 ING1 may not be a major candidate tumor suppressor gene in myeloid leukemias. Am. J. Hematol. 69:141–143, 2002. © 2002 Wiley‐Liss, Inc.