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Radiation therapy and combination of cladribine, cyclophosphamide, and prednisone as treatment of Bing‐Neel syndrome: Case report and review of the literature
Author(s) -
Delgado Julio,
Canales Miguel Angel,
Garcia Beatriz,
AlvarezFerreira Javier,
GarciaGrande Antonio,
HernandezNavarro Fernando
Publication year - 2002
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.10023
Subject(s) - medicine , macroglobulinemia , waldenstrom macroglobulinemia , lymphoplasmacytic lymphoma , hyperviscosity syndrome , prednisone , radiation therapy , cyclophosphamide , lymphoma , central nervous system , cladribine , pathology , chemotherapy , multiple myeloma
Waldenström's macroglobulinemia is a low‐grade lymphoma that produces monoclonal IgM. Central nervous system symptoms are frequent in Waldenström's macroglobulinemia, mostly associated with blood hyperviscosity. Nevertheless, central nervous system infiltration by malignant cells (Bing‐Neel syndrome) has rarely been reported. We describe the case of a 72‐year‐old man with Waldenstrom's macroglobulinemia and central nervous system infiltration by malignant cells with tumor formation. All similar cases reported in the literature are reviewed and the different therapeutic approaches discussed. Am. J. Hematol. 69:127–131, 2002. © 2002 Wiley‐Liss, Inc.