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Restricted expression of the ron gene encoding the macrophage stimulating protein receptor during mouse development
Author(s) -
Quantin Béatrice,
Schuhbaur Brigitte,
Gesnel MarieClaude,
Dollé Pascal,
Breathnach Richard
Publication year - 1995
Publication title -
developmental dynamics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.634
H-Index - 141
eISSN - 1097-0177
pISSN - 1058-8388
DOI - 10.1002/aja.1002040405
Subject(s) - biology , receptor tyrosine kinase , gene , microbiology and biotechnology , transmembrane protein , complementary dna , northern blot , receptor , 5 ht5a receptor , gene expression , lrp1b , tropomyosin receptor kinase c , ror1 , tyrosine kinase , genetics , growth factor , hspa2 , platelet derived growth factor receptor , peptide sequence
Abstract The human ron gene codes for a transmembrane protein tyrosine kinase which is a receptor for the macrophage stimulating protein. The ron receptor, together with the hepatocyte growth factor/scatter factor receptor encoded by the proto‐oncogene met , and the product of the c ‐ sea proto‐oncogene, make up a family of structurally related receptors. We have cloned murine ron cDNA sequences and used them as probes for in situ hybridization and Northern blot experiments. We show that ron gene expression occurs relatively late in development, and is much more restricted than that of the met gene. ron gene expression is detected in specific areas of the central and the peripheric nervous system, as well as in discrete cells in developing bones, and in the glandular epithelia along the digestive tract. © 1995 wiley‐Liss, Inc.