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Expression of M‐twist during postimplantation development of the mouse
Author(s) -
Füchtbauer Ernstmartin
Publication year - 1995
Publication title -
developmental dynamics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.634
H-Index - 141
eISSN - 1097-0177
pISSN - 1058-8388
DOI - 10.1002/aja.1002040309
Subject(s) - mesenchyme , biology , mesoderm , primitive streak , twist , microbiology and biotechnology , organogenesis , anatomy , cartilage , gene , genetics , embryo , embryonic stem cell , geometry , mathematics
The murine homologue of the Drosophila twist gene has been shown to be essential for head mesenchyme formation and to act as an inhibitor of muscle differentiation. This paper presents a detailed analysis of M‐twist expression patterns from day 7 post coitum (p.c.) to day 18 p.c., indicating a more general function of the M‐twist gene. At day 7 p.c., M‐twist is expressed in the mesoderm outside the primitive streak. Later M‐twist message is predominantly found in the somites, the head mesenchyme, the branchial arches, the limbs, and in the mesenchyme underneath the epidermis. Beginning at day 8 p.c., M‐twist is mainly expressed in undifferentiated cells committed to muscle and cartilage development: this exspression is consistent with a suggested role of M‐twist in inhibiting overt muscle and cartilage differentiation. However, during organogenesis, M‐twistt is expressed in several areas of mesenchyme‐epithelia interactions, suggesting additional tissue specific functions. © 1995 wiley‐Liss, Inc.