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Diffusion or autocatalysis of retinoic acid cannot explain pattern formation in the chick wing bud
Author(s) -
Papageorgiou S.,
Almirantis Y.
Publication year - 1992
Publication title -
developmental dynamics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.634
H-Index - 141
eISSN - 1097-0177
pISSN - 1058-8388
DOI - 10.1002/aja.1001940404
Subject(s) - retinoic acid , autocatalysis , biology , zone of polarizing activity , diffusion , limb bud , morphogen , microbiology and biotechnology , biochemistry , ectoderm , embryogenesis , embryo , gene , physics , thermodynamics , catalysis
We have collected several experimental data of pattern duplications due to the ZPA transplantation or application of retinoic acid on the developing chick limb bud. We have compared these data with the predictions of models based on diffusion or autocatalysis of retinoids. It turns out that these models cannot comprehensively explain the data. More specifically, retinoic acid cannot be either diffusing from a ZPA source or participate in an autocatalytic gradient formation. © 1992 Wiley‐Liss, Inc.