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Development of olfactory nerve glia defined by a monoclonal antibody specific for schwann cells
Author(s) -
Norgren Robert B.,
Ratner Nancy,
Brackenbury Robert
Publication year - 1992
Publication title -
developmental dynamics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.634
H-Index - 141
eISSN - 1097-0177
pISSN - 1058-8388
DOI - 10.1002/aja.1001940308
Subject(s) - biology , monoclonal antibody , olfactory ensheathing glia , schwann cell , microbiology and biotechnology , neuregulin , neuroglia , neuroscience , olfactory system , immunology , antibody , olfactory bulb , central nervous system , signal transduction
Although there is considerable interest in the possible role of olfactory glia in the pathfinding abilities of olfactory nerve axons, the complete development of these glia in vivo has not been described. Using a specific Schwann cell marker, the 1E8 antibody, we have found that olfactory nerve glia can be identified throughout development. These glia appear to originate in the olfactory placode and migrate initially into the periphery of the olfactory nerve, and later into the center of the nerve. Olfactory nerve glia enter the presumptive olfactory bulb with the olfactory receptor neuron axons and distribute themselves along the edge of the olfactory nerve layer. The fact that olfactory nerve glia are specifically immunostained by the 1E8 monoclonal antibody, which recognizes the Schwann cell‐specific protein P 0 , suggests that these cells more closely resemble Schwann cells than astrocytes or enteric glia. These results support and extend previous findings suggesting that olfactory nerve glia have distinctive developmental and anatomical features which may be important to the regenerative capacity of the olfactory system. © 1992 Wiley‐Liss, Inc.