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MyoD and myogenin are coexpressed in regenerating skeletal muscle of the mouse
Author(s) -
Füchtbauer ErnstMartin,
Westphal Heiner
Publication year - 1992
Publication title -
developmental dynamics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.634
H-Index - 141
eISSN - 1097-0177
pISSN - 1058-8388
DOI - 10.1002/aja.1001930106
Subject(s) - myogenin , myogenesis , myod , biology , skeletal muscle , myogenic regulatory factors , myocyte , regeneration (biology) , microbiology and biotechnology , immunostaining , endocrinology , immunohistochemistry , immunology
The differential expression of genes triggering myogenesis might cause or reflect differences among myoblasts. Little is known about the presence of MyoD1 and myogenin during the process of regeneration. We therefore examined the expression of MyoD1 and myogenin in muscle regeneration after grafting. Immunostaining of regenerating skeletal muscle of the mouse revealed the presence of both MyoD1 and myogenin. In mononucleated cells the proteins were not detected until shortly before fusion into myotubes. They persisted in the nuclei of regenerated muscle fibers for at least 2 weeks. MyoD1 and myogenin were not detected in nonregenerating control muscle.