Open AccessEndemic hepatitis B and C virus areas are associated with lower prevalence of hyperlipidemia: Ecological and cross‐sectional studies
Author(s) -
Chen ChaoTung,
Huang WeiCheng,
Wang JingHoung,
Lee ChuanMo,
Hung ChaoHung,
Tsai LinSan,
Chen ShuChuan,
Lin ShengChe,
Lu ShengNan,
Kee KwongMing
Publication year - 2017
Publication title -
advances in digestive medicine
Language(s) - English
Resource type - Journals
ISSN - 2351-9800
DOI - 10.1002/aid2.12054
Subject(s) - hypertriglyceridemia , medicine , hbsag , cross sectional study , triglyceride , gastroenterology , hyperlipidemia , hepatitis b virus , hepatitis b , immunology , cholesterol , diabetes mellitus , virus , endocrinology , pathology
Summary Backgrounds Patients with chronic hepatitis B virus (HBV) or hepatitis C virus (HCV) infection have been documented to have lower levels of cholesterol and triglyceride. This study attempts to validate this correlation from ecological and cross‐sectional research in community. Methods A total of 56,336 subjects in 533 villages of Tainan County underwent health screening in 2004. The antibody to HCV (anti‐HCV), Hepatitis B surface antigen (HBsAg), total cholesterol and triglyceride levels were checked. We used village as a unit to analyze the correlations between prevalence of HBsAg or anti‐HCV and hypercholesterolemia or hypertriglyceridemia. Statistical analyses were simple linear regression and Student t test. Results Mean serum cholesterol and triglyceride levels were both significantly lower in subjects with HBV and HCV infection (all p < 0.001). Village‐specific prevalence rates of hypercholesterolemia ( r = – 0.15) and hypertriglyceridemia (r = – 0.21) were negative correlated with prevalence of HBsAg significantly (all p < 0.001). Village‐specific prevalence rates of hypercholesterolemia (r = ‐ 0.323) and hypertriglyceridemia ( r = ‐ 0.258) were also negative correlated with prevalence of anti‐HCV significantly (all p < 0.001). Conclusions In this community‐based study, endemic villages of HBV or HCV infection were associated with a lower prevalence of hypercholesterolemia and hypertriglyceridemia. Copyright © 2017, The Gastroenterological Society of Taiwan, The Digestive Endoscopy Society of Taiwan and Taiwan Association for the Study of the Liver.