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Optimal design of interconnected bioreactors: New results
Author(s) -
Harmand Jérôme,
Rapaport Alain,
Trofino Alexandre
Publication year - 2003
Publication title -
aiche journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.958
H-Index - 167
eISSN - 1547-5905
pISSN - 0001-1541
DOI - 10.1002/aic.690490609
Subject(s) - bioreactor , optimal design , volume (thermodynamics) , steady state (chemistry) , volumetric flow rate , control theory (sociology) , process engineering , loop (graph theory) , continuous flow , flow (mathematics) , computer science , mathematics , biochemical engineering , engineering , chemistry , mechanics , thermodynamics , physics , control (management) , organic chemistry , combinatorics , artificial intelligence , machine learning
The optimal design of two interconnected continuous stirred bioreactors in which a single reaction occurs is presented. The term “optimal” should be understood here as the minimum of the total volume of the reactors required to perform a given conversion rate, given a quantity of matter to be converted per time unit. In determining the optimal volume, it is assumed that the input flow may be distributed among the tanks and also that a recirculation loop can be used. The analysis of the optimal configurations is investigated, and the concept of “steady‐state equivalent biological system” is highlighted. The class of growth functions for which the results of this study hold is quite wide and includes, in particular, Monod, Haldane, and Aiba kinetics.