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High‐dimensional solid‐liquid phase diagrams involving compounds and polymorphs
Author(s) -
Wibowo Christianto,
Samant Ketan D.,
Ng Ka M.
Publication year - 2002
Publication title -
aiche journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.958
H-Index - 167
eISSN - 1547-5905
pISSN - 0001-1541
DOI - 10.1002/aic.690481009
Subject(s) - phase diagram , crystallization , isobaric process , isothermal process , thermodynamics , polymorphism (computer science) , phase (matter) , visualization , materials science , chemistry , organic chemistry , computer science , physics , data mining , biochemistry , gene , genotype
A systematic procedure for the generation and visualization of high‐dimensional isobaric phase diagrams for systems exhibiting compound formation and/or polymorphism is presented. Such phase diagrams are useful in synthesizing crystallization‐based separation processes for systems involving compounds and polymorphs, which are common in the production of pharmaceuticals. Polythermal as well as isothermal phase diagrams of multicomponent systems can be generated. Examples are provided to illustrate the procedure.