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Design of reactive extraction systems for bioproduct recovery
Author(s) -
Pai Rajaram A.,
Doherty Michael F.,
Malone Michael F.
Publication year - 2002
Publication title -
aiche journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.958
H-Index - 167
eISSN - 1547-5905
pISSN - 0001-1541
DOI - 10.1002/aic.690480310
Subject(s) - chemistry , extraction (chemistry) , bioprocess , citric acid , chromatography , amine gas treating , aqueous solution , yield (engineering) , penicillin , reactive distillation , organic chemistry , chemical engineering , antibiotics , biochemistry , materials science , distillation , engineering , metallurgy
Abstract Liquid‐liquid extraction, combined with chemical reaction, can improve overall yields of product. Reactive extraction is an alternative for separations in bioprocessing, for example, for the production of carboxylic acids such as lactic or citric acid, alcohols such as ethanol, or antibiotics such as penicillin, cephalosporin or streptomycin. A method for the design of reactive extraction cascades was used for the recovery of Penicillin G and for lactic acid from aqueous mixtures using mixtures of organic solvents with reactive amines as extractants. Effects of such variables as residence time, flow rates, pH, number of stages and amine concentration are quantified. Designs capable of essentially complete recovery are reported.