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Shortcut experimental method for designing chiral SMB separations
Author(s) -
Migliorini Cristiano,
Mazzotti Marco,
Zei Gianmarco,
Morbidelli Massimo
Publication year - 2002
Publication title -
aiche journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.958
H-Index - 167
eISSN - 1547-5905
pISSN - 0001-1541
DOI - 10.1002/aic.690480109
Subject(s) - simulated moving bed , cellulose triacetate , microcrystalline cellulose , adsorption , mass transfer , chromatography , chemistry , microcrystalline , enantiomer , cellulose , nonlinear system , chromatographic separation , process engineering , high performance liquid chromatography , engineering , physics , organic chemistry , quantum mechanics , crystallography
The simulated moving‐bed (SMB) chromatographic separation of the Tröger's base enantiomers with ethanol as eluent on microcrystalline triacetate cellulose was studied. An experimental technique to design nonlinear SMB separations with few column experiments is presented. This shortcut technique allows the rigorous solution of the Equilibrium Theory model to be approximated without knowing the adsorption equilibria, and therefore can be useful in developing new separations. The predictions of the shortcut method are compared with the experimental results of the SMB separation. The effect of the feed concentration and of the nonideal contributions, such as mass‐transfer resistance and extracolumn band broadening, are elucidated.