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Effect of relative solubility on amino acid crystal purity
Author(s) -
Givand Jeffrey C.,
Teja Amyn S.,
Rousseau Ronald W.
Publication year - 2001
Publication title -
aiche journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.958
H-Index - 167
eISSN - 1547-5905
pISSN - 0001-1541
DOI - 10.1002/aic.690471210
Subject(s) - isoleucine , solubility , chemistry , impurity , leucine , solvent , amino acid , crystal structure , aqueous solution , crystal (programming language) , inorganic chemistry , crystallography , organic chemistry , biochemistry , computer science , programming language
The ratio of the pure‐component solubility of a primary solute to that of an impurity in the same solvent has a dramatic impact on crystal purity when lattice substitution is the dominant mechanism of impurity incorporation in the crystal. This is demonstrated for a model system of isoleucine and leucine in which leucine is the impurity. The pure‐component solubility ratios of isoleucine to leucine in mixed solvents were measured and used to select solvents that could affect the lattice substitution of leucine in isoleucine crystals. Addition of electrolytes and/or cosolvents to aqueous solutions of the two amino acids improved the purity of isoleucine crystals obtained by cooling.