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Synthesis of chiral crystallization processes
Author(s) -
Schroer Joseph W.,
Wibowo Christianto,
Ng Ka M.
Publication year - 2001
Publication title -
aiche journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.958
H-Index - 167
eISSN - 1547-5905
pISSN - 0001-1541
DOI - 10.1002/aic.690470214
Subject(s) - racemization , naproxen , crystallization , ibuprofen , phase diagram , resolution (logic) , phase (matter) , chemistry , combinatorial chemistry , separation process , process (computing) , chiral stationary phase , organic chemistry , materials science , chromatography , computer science , artificial intelligence , medicine , alternative medicine , pathology , pharmacology , operating system
A process synthesis procedure is presented for the resolution of racemic mixtures by crystallizaiion. The phase behaviors of racemic mixtures and of those in the presence of solvents and resolving agents are discussed. The Corresponding separation schemes are synthesized by considering the separation steps in a flowsheet as movements on a phase diagram. Separations with and without involving racemization and deracemization are considered. The procedure is illustrated with several examples, including the manufacture of ibuprofen and naproxen.