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Modeling shock layers in ion‐exchange displacement chromatography
Author(s) -
Natarajan Venkatesh,
Cramer Steven M.
Publication year - 1999
Publication title -
aiche journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.958
H-Index - 167
eISSN - 1547-5905
pISSN - 0001-1541
DOI - 10.1002/aic.690450104
Subject(s) - mass transfer , chemistry , displacement (psychology) , mechanics , classification of discontinuities , volumetric flow rate , displacement chromatography , shock (circulatory) , ion chromatography , ion , chromatography , thermodynamics , analytical chemistry (journal) , physics , mathematics , supercritical fluid chromatography , gas chromatography , organic chemistry , mathematical analysis , medicine , psychotherapist , psychology
Abstract In ideal displacement chromatography (systems with infinite mass‐transfer kinetics), various solutes are separated by sharp discontinuities. In real systems, however, the shocks are eroded into shock layers because of the finite rates of mass transfer. The thickness of these shock layers, which can reduce the yields achievable in these systems, depend on the flow rate, particle diameter and the “difficulty” of these separations. The steric mass action formalism of ion‐exchange chromatography was used in concert with a solid film linear driving force model to describe the effects of flow rate, particle diameter, and the degree of difficulty of the separation on ion‐exchange displacement systems. Simple pulse techniques are employed to estimate the thermodynamic and mass‐transfer parameters. The simulations are then compared to experimental results over a range of conditions. The results demonstrate that this relatively simple modeling approach can be employed to describe the behavior of these nonideal displacement systems.