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Modeling strategies for enantiomers separation by SMB chromatography
Author(s) -
Pais Luís S.,
Loureiro José M.,
Rodrigues Alírio E.
Publication year - 1998
Publication title -
aiche journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.958
H-Index - 167
eISSN - 1547-5905
pISSN - 0001-1541
DOI - 10.1002/aic.690440307
Subject(s) - simulated moving bed , raffinate , chromatography , steady state (chemistry) , enantiomer , separation (statistics) , chemistry , flow (mathematics) , packed bed , transient (computer programming) , mechanics , mathematics , computer science , adsorption , statistics , physics , organic chemistry , extraction (chemistry) , operating system
Modeling strategies for simulated moving bed adsorbers were studied to compare the simulated moving bed model (SMB) that considers the real shift of the injection and collection points to the true moving bed approach (TMB) that considers liquid and solid flow in opposite directions. The prediction of these two models is compared in terms of steady‐state performance, steady‐state internal concentration profiles, and transient behavior of the extract and raffinate purities. The influence of the degree of subdivision of the bed in the SMB model predictions is also analyzed and compared with the TMB performance. Model results are compared with experimental results obtained for the chromatographic separation of binaphthol enantiomers.