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Production rate of an isotachic train in displacement chromatography
Author(s) -
Zhu Jie,
Guiochon Georges
Publication year - 1995
Publication title -
aiche journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.958
H-Index - 167
eISSN - 1547-5905
pISSN - 0001-1541
DOI - 10.1002/aic.690410106
Subject(s) - mechanics , volumetric flow rate , yield (engineering) , dispersion (optics) , displacement (psychology) , mass transfer , flow (mathematics) , shock (circulatory) , chemistry , phase (matter) , particle (ecology) , chromatography , mathematics , materials science , thermodynamics , physics , optics , geology , medicine , psychology , oceanography , organic chemistry , psychotherapist
The shock layer theory permits the derivation of an equation relating the thickness of the shock layer or mixed zone between successive bands in a fully developed isotachic train and the experimental parameters (mobile‐phase flow velocity, concentration and retention factor of the displacer, column length, and average particle size of the packing material). It also permits the calculation of the amount of each product contained in this mixed zone. The main assumptions made are the use of the competitive Langmuir isotherm, the identity of axial dispersion coefficients, and the mass‐transfer rate constants for different components. These equations make it possible to calculate the production rate and recovery yield achieved with an isotachic train, and to optimize the experimental conditions for maximum production rate. The shock layer thickness increases rapidly and the production rate decreases sharply when α‐1 tends toward 0. In agreement with previous experimental results, there are well defined optimum flow velocity and displacer concentrations which vary depending on feed components. This theory permits an easy access to the optimization of these parameters.