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Multicomponent separation using a column‐switching chromatographic method
Author(s) -
Ching C. B.,
Chu K. H.,
Hidajat K.
Publication year - 1994
Publication title -
aiche journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.958
H-Index - 167
eISSN - 1547-5905
pISSN - 0001-1541
DOI - 10.1002/aic.690401108
Subject(s) - countercurrent exchange , chromatography , elution , chemistry , simulated moving bed , process (computing) , mass transfer , volumetric flow rate , binary number , flow (mathematics) , dispersion (optics) , separation process , column (typography) , separation (statistics) , analytical chemistry (journal) , mechanics , computer science , mathematics , thermodynamics , engineering , adsorption , mechanical engineering , physics , arithmetic , organic chemistry , connection (principal bundle) , machine learning , optics , operating system
A cyclic chromatographic process based on the method of column switching was used to separate a three‐component carbohydrate mixture. It permits continuous introduction of the feed and is designed to produce higher product concentration compared to a normal elution cyclic process. A fixed‐bed model incorporating axial dispersion and a linear driving force for mass transfer was successfully used to estimate optimum operating conditions (switch times and fluid‐flow rates). Its experimental setup can be easily constructed by modifying the apparatus of a simulated countercurrent process since both systems comprise segmented columns equipped with on‐off valves for fluid‐flow control. This allows one to conduct either multicomponent separation based on elution operation or binary separation based on countercurrent operation using essentially the same set of experimental apparatus with minor modification.