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Optimizing experimental conditions for minimum production cost in preparative chromatography
Author(s) -
Felinger Attila,
Guiochon Georges
Publication year - 1994
Publication title -
aiche journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.958
H-Index - 167
eISSN - 1547-5905
pISSN - 0001-1541
DOI - 10.1002/aic.690400404
Subject(s) - yield (engineering) , chromatography , volumetric flow rate , chemistry , solvent , column chromatography , process engineering , materials science , mathematics , mechanics , engineering , physics , organic chemistry , composite material
Optimum experimental conditions and column design parameters are calculated for most economical separation of binary mixtures by preparative liquid chromatography. The solvent consumption and capital costs are regarded as the two major cost contributions. Calculations were performed by using the numerical solution of the equilibrium‐dispersive model of chromatography and a nonlinear simplex algorithm. Solvent consumption depends only on the column efficiency, the retention factor, and the loading factor. The production rate depends on the particle size, the column length, the mobile‐phase flow velocity, the retention and the loading factors, and can be optimized with or without recovery yield constraints. A hybrid objective function was constructed to find the tradeoffs between the production rate and the solvent consumption.