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Analysis of bioproduct separation using gel‐enclosed adsorbents
Author(s) -
Nigam Somesh C.,
Siahpush Ali R.,
Wang Henry Y.
Publication year - 1990
Publication title -
aiche journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.958
H-Index - 167
eISSN - 1547-5905
pISSN - 0001-1541
DOI - 10.1002/aic.690360813
Subject(s) - adsorption , porosity , chromatography , chemistry , chemical engineering , matrix (chemical analysis) , membrane , diffusion , aqueous solution , ion exchange , materials science , ion , organic chemistry , thermodynamics , biochemistry , physics , engineering
The concept of “gel‐enclosed” adsorbents was recently introduced for whole fermentation broth processing. The term “gel‐enclosed adsorbents” in this paper refers to small adsorbent particles such as the ones used in affinity or ion‐exchange chromatography enclosed within a protective, spherical, semipermeable gel barrier. The barrier can be in the form of an entrapment matrix where a porous gel matrix in itself contains entrapped adsorbent particles, or in the form of an encapsulating membrane where an aqueous spherical core containing the adsorbent particles is enclosed by a gel membrane. Both experimental and theoretical analyses were carried out to elicit a more fundamental view of the diffusion and adsorption phenomena occurring within these forms of adsorbents. Furthermore, the effective porosity of the gel matrix and the effective diffusivities of the species being separated, as well as their adsorption behavior combined result in what is here termed “kinetic selectivity”.