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Representation of the solubility behavior of amino acids in water
Author(s) -
Nass Kathryn K.
Publication year - 1988
Publication title -
aiche journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.958
H-Index - 167
eISSN - 1547-5905
pISSN - 0001-1541
DOI - 10.1002/aic.690340804
Subject(s) - solubility , chemistry , dilution , aqueous solution , amino acid , representation (politics) , crystallization , thermodynamics , function (biology) , activity coefficient , consistency (knowledge bases) , biological system , chromatography , organic chemistry , mathematics , biochemistry , physics , evolutionary biology , politics , biology , political science , law , geometry
Expressions suitable for the description of the behavior of small biological zwitterions in aqueous systems are developed. The validity and usefulness of the expressions are tested by correlating data for the activity coefficients of several amino acids in water. Development of rational expressions for the solid‐liquid equilibria (SLE) of amino acids, in terms of the heat of solution at infinite dilution, is also presented. The solubility data of phenylalanine, tyrosine and diiodotyrosine as a function of pH are successfully correlated using the approach developed here. In addition, simultaneous correlation of the pH and temperature dependence of solubility data for diodotyrosine in water gives very good representation. The expressions described here should prove useful for the design and optimization of separation processes, such as crystallization, with minimal experimental information.