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A simultaneous transport‐reaction model for controlled drug delivery from catalyzed bioerodible polymer matrices
Author(s) -
Thombre A. G.,
Himmelstein K. J.
Publication year - 1985
Publication title -
aiche journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.958
H-Index - 167
eISSN - 1547-5905
pISSN - 0001-1541
DOI - 10.1002/aic.690310509
Subject(s) - orthoester , catalysis , matrix (chemical analysis) , diffusion , polymer , kinetics , chemistry , drug delivery , chemical engineering , combinatorial chemistry , materials science , organic chemistry , chromatography , thermodynamics , engineering , physics , quantum mechanics
Abstract A simultaneous diffusion‐reaction model is presented for the analysis of the kinetics of a chemically eroding poly(orthoester) matrix incorporated with a bioactive agent and with a catalyst to promote the erosion. Simulation results are consistent with experimentally observed hollow residuals and provide a basis for analyzing various design options.