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Rate of protein absorption and desorption on cellulosic ion exchangers
Author(s) -
Graham Edgar E.,
Fook Chen F.
Publication year - 1982
Publication title -
aiche journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.958
H-Index - 167
eISSN - 1547-5905
pISSN - 0001-1541
DOI - 10.1002/aic.690280212
Subject(s) - desorption , adsorption , diffusion , chemistry , ion exchange , cellulose , absorption (acoustics) , chromatography , analytical chemistry (journal) , absorption rate , ion , ion exchange resin , chemical engineering , thermodynamics , inorganic chemistry , materials science , organic chemistry , composite material , physics , engineering
Both equilibrium and rate studies were made for the adsorption and desorption of Bovine Serum Albumin (B.S.A.), Fraction V , from dilute solutions using a new cellulose based ion exchange resin. Using the equilibrium data and a simple two‐film theory to describe the rate data it was shown that during the initial perioid of adsorption the rate was controlled by film diffusion, after which it was controlled by intraparticle diffusion. The desorption was largely intraparticle diffusion controlled except for a very short surface desorption step. It is suggested that the model could be used to describe other protein adsorption/ion exchange processes.