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An experimental investigation of stability and multiplicity of steady states in a biological reactor
Author(s) -
DiBiasio David,
Lim H. C.,
Weigand W. A.
Publication year - 1981
Publication title -
aiche journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.958
H-Index - 167
eISSN - 1547-5905
pISSN - 0001-1541
DOI - 10.1002/aic.690270216
Subject(s) - continuous stirred tank reactor , yield (engineering) , multiplicity (mathematics) , stability (learning theory) , bioenergetics , metabolite , substrate (aquarium) , chemistry , thermodynamics , biological system , physics , mathematics , biology , biochemistry , computer science , ecology , mathematical analysis , machine learning , mitochondrion
The existence of multiple stable and unstable steady states in a continuous stirred tank biological reactor (CSTBR) was demonstrated experimentally for the first time. These experiments resulted in the determination of growth rate, yield and intermediate metabolite concentration data entirely from continuous culture. This information was used to qualitatively interpret the stability behavior in terms of the biochemistry and bioenergetics of substrate metabolism.