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Steady state diffusion of oxygen in red blood cell and model suspensions
Author(s) -
Stroeve Pieter,
Colton Clark K.,
Smith Kenneth A.
Publication year - 1976
Publication title -
aiche journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.958
H-Index - 167
eISSN - 1547-5905
pISSN - 0001-1541
DOI - 10.1002/aic.690220626
Subject(s) - oxygen , hemoglobin , chemistry , permeation , oxygen transport , red blood cell , red cell , diffusion , permeability (electromagnetism) , suspension (topology) , chromatography , steady state (chemistry) , chemical engineering , biophysics , membrane , thermodynamics , biochemistry , organic chemistry , physics , computer security , mathematics , homotopy , biology , computer science , pure mathematics , engineering
Experimental measurements were made of the steady oxygen permeation rate through films of nonreactive and reactive dispersions, including suspensions of red blood cells. The data compare well with a theoretical analysis which incorporates a one‐step reversible reaction within the dispersed phase. In the absence of reaction, the red cell permeability could be treated as that of a concentrated hemoglobin solution. For reactive suspensions of red cells or water‐in‐oil emulsions containing hemoglobin at 25°C, substantial facilitation of oxygen transport occurred when oxyhemoglobin gradients were steep, but both the data and the theory exhibited considerably less facilitation than would be suggested by an equilibrium analysis.