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Scopolamine permation through human skin in vitro
Author(s) -
Chandrasekaran S. K.,
Michaels A. S.,
Campbell P. S.,
Shaw J. E.
Publication year - 1976
Publication title -
aiche journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.958
H-Index - 167
eISSN - 1547-5905
pISSN - 0001-1541
DOI - 10.1002/aic.690220503
Subject(s) - penetrant (biochemical) , permeation , sorption , stratum corneum , chemistry , lag time , chromatography , thermal diffusivity , membrane , dissolution , thermodynamics , adsorption , organic chemistry , biochemistry , biological system , physics , pathology , biology , medicine
The sorption and rate of permeation of scopolamine base in human skin have been measured as a function of drug concentration in aqueous solution contacting the stratum corneum surface of the skin. The sorption isotherm is nonlinear, and the apparent penetrant diffusivity computed from steady state permeation data is greater than that estimated from unsteady state (time lag) measurements. By assuming that sorption occurs by both ordinary dissolution and binding of penetrant to immobile sites in the membrane, the experimental sorption isotherm can be predicted, and the disparity between steady state and time lag diffusivities can be reconciled.