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A thermodynamic method of predicting the transport of steroids in polymer matrices
Author(s) -
Michaels A. S.,
Wong P. S. L.,
Prather R.,
Gale R. M.
Publication year - 1975
Publication title -
aiche journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.958
H-Index - 167
eISSN - 1547-5905
pISSN - 0001-1541
DOI - 10.1002/aic.690210605
Subject(s) - solubility , polymer , steroid , hildebrand solubility parameter , entropy (arrow of time) , thermodynamics , fusion , chemistry , permeability (electromagnetism) , flory–huggins solution theory , organic chemistry , membrane , physics , biochemistry , linguistics , philosophy , hormone
Application of Hildebrand's theory of the solubility of microsolutes in ordinary solvents, and of the Flory‐Huggins theory to the solubility of steroids in polymers, has permitted the derivation of a predictive correlation between polymer permeability and steroid crystalline melting temperature, other correlating parameters being the entropy of fusion of the steroid and the (computed) solubility parameters of steroid and polymer. The correlation permits prediction of the permeability of any steroid in any polymer with reasonable accuracy.