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Flow, suspension and mixing dynamics in DASGIP bioreactors, Part 2
Author(s) -
Samaras Jasmin J.,
Ducci Andrea,
Micheletti Martina
Publication year - 2020
Publication title -
aiche journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.958
H-Index - 167
eISSN - 1547-5905
pISSN - 0001-1541
DOI - 10.1002/aic.16999
Subject(s) - impeller , suspension (topology) , mixing (physics) , microcarrier , bioreactor , agitator , paddle , mechanics , settling , mass transfer , flow (mathematics) , materials science , baffle , chemistry , chemical engineering , environmental science , physics , engineering , environmental engineering , mathematics , composite material , biochemistry , organic chemistry , quantum mechanics , homotopy , pure mathematics , cell
This work aims to characterize the mixing and suspension dynamics occurring within two commercially available DASGIP bioreactor configurations, equipped with a two‐blade paddle impeller with large impeller to tank diameter ratio, D / T = 0.97. Both continuous and intermittent agitation modes were employed to determine the impact that agitation strategy has upon mass transfer and microcarrier settling/suspension. This paper builds upon the flow dynamics data presented in Part 1 for a flat bottom DASGIP bioreactor and shows how intermittent agitation can break‐up regions of slow mixing observed during continuous agitation, therefore substantially increasing the mixing efficiency of the system. Similarly, it was found that microcarrier characteristics might significantly affect the level of suspension when the impeller is in dwell status when intermittent agitation modes are used.