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Application of chemical reaction engineering principles to “body‐on‐a‐chip” systems
Author(s) -
Sung Jong Hwan,
Wang Ying I.,
Kim Jung Hun,
Lee Jong Min,
Shuler Michael L.
Publication year - 2018
Publication title -
aiche journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.958
H-Index - 167
eISSN - 1547-5905
pISSN - 0001-1541
DOI - 10.1002/aic.16448
Subject(s) - microscale chemistry , biochemical engineering , organ system , chip , computer science , organ on a chip , complex system , biological system , nanotechnology , engineering , biology , materials science , artificial intelligence , microfluidics , medicine , telecommunications , mathematics education , mathematics , disease , pathology
The combination of cell culture models with microscale technology has fostered emergence of in vitro cell‐based microphysiological models, also known as organ‐on‐a‐chip systems. Body‐on‐a‐chip (BOC) systems, which are multiorgan systems on a chip to mimic physiological relations, enable recapitulation of organ–organ interactions and potentially whole‐body response to drugs, as well as serve as models of diseases. Chemical reaction engineering principles can be applied to understanding complex reactions inside the cell or human body, which can be treated as a multireactor system. These systems use physiologically based pharmacokinetic models to guide the development of microscale systems of the body where organs or tissues are represented by living cells or tissues, and integrated into BOC systems. Here, we provide a brief overview on the concept of chemical reaction engineering and how its principles can be applied to understanding and predicting the behavior of BOC systems. © 2018 American Institute of Chemical Engineers AIChE J , 64: 4351–4360, 2018