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Crystallization of selective polymorph using relationship between supersaturation and solubility
Author(s) -
Kim KwangJoo,
Doherty Michael F.
Publication year - 2015
Publication title -
aiche journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.958
H-Index - 167
eISSN - 1547-5905
pISSN - 0001-1541
DOI - 10.1002/aic.14745
Subject(s) - supersaturation , nucleation , crystallization , solubility , metastability , thermodynamics , polymorphism (computer science) , kinetics , amorphous solid , crystallography , chemistry , materials science , organic chemistry , physics , biochemistry , quantum mechanics , genotype , gene
For polymorph screening, the plot of ΔC met /C c against C * /C c in nucleation kinetics was investigated. The polymorph screening for forms I and II and amorphous form of clopidogrel hydrogen sulfate was carried out according to the nucleation kinetics expressed by this plot. The stability order of polymorphs for famotidin was also predicted successfully by this model. This model was used in the expectation of supersaturation level for polymorphic formation. Two types of polymorphic crystallization: transformation from metastable form to stable form and nucleation and growth of polymorphic form without transformation can be explained. Amorphous form was also expected by this model. Even though polymorphs depend on lots of crystallization parameters such as solvent, temperature, concentration, cooling rate, and so forth, plot of ΔC met /C c and the C * /C c in various nucleation kinetics gives a guide line for screening of polymorph. © 2015 American Institute of Chemical Engineers AIChE J , 61: 1372–1379, 2015