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A multiscale, biophysical model of flow‐induced red blood cell damage
Author(s) -
Vitale Flavia,
Nam Jaewook,
Turchetti Luca,
Behr Marek,
Raphael Robert,
Annesini Maria Cristina,
Pasquali Matteo
Publication year - 2014
Publication title -
aiche journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.958
H-Index - 167
eISSN - 1547-5905
pISSN - 0001-1541
DOI - 10.1002/aic.14318
Subject(s) - hemolysis , red blood cell , hemoglobin , membrane , computational fluid dynamics , multiscale modeling , blood flow , flow (mathematics) , mechanics , biophysics , fluid dynamics , blood cell , chemistry , biological system , materials science , physics , biology , medicine , biochemistry , immunology , computational chemistry
A new model for mechanically induced red blood cell damage is presented. Incorporating biophysical insight at multiple length scales, the model couples flow‐induced deformation of the cell membrane (∼10 µ m) to membrane permeabilization and hemoglobin transport (∼100 nm). We estimate hemolysis in macroscopic (above ∼1 mm) 2‐D inhomogeneous blood flow by computational fluid dynamics (CFD) and compare results with literature models. Simulations predict the effects of local flow field on RBC damage, due to the combined contribution of membrane permeabilization and hemoglobin transport. The multiscale approach developed here lays a foundation for a predictive tool for the optimization of hydrodynamic and hematologic design of cardiovascular prostheses and blood purification devices. © 2014 American Institute of Chemical Engineers AIChE J , 60: 1509–1516, 2014