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Precipitation of hydroxyapatite at 37 °C in a meso oscillatory flow reactor operated in batch at constant power density
Author(s) -
Castro Filipa,
Ferreira António,
Rocha Fernando,
Vicente António,
Teixeira José António
Publication year - 2013
Publication title -
aiche journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.958
H-Index - 167
eISSN - 1547-5905
pISSN - 0001-1541
DOI - 10.1002/aic.14193
Subject(s) - mixing (physics) , continuous stirred tank reactor , precipitation , materials science , batch reactor , nanoparticle , analytical chemistry (journal) , power density , continuous reactor , chemical engineering , chemistry , thermodynamics , chromatography , power (physics) , nanotechnology , physics , catalysis , quantum mechanics , biochemistry , meteorology , engineering
A meso oscillatory flow reactor (meso‐OFR) was successfully applied for the precipitation of hydroxyapatite (HAp) nanoparticles. Mixing efficiency of the mesoreactor operated batchwise in a vertical tube was evaluated at constant power density, by monitoring variation of hue values upon mixing both spatially and temporally. The best operating conditions for fast mixing and a more homogeneous reaction medium were verified for f = 0.83 Hz and x 0 = 4.5 mm. HAp precipitation was then carried out under these conditions at 37 °C for different mixing Ca/P molar ratios. HAp nanoparticles with a mean size (d 50 ) of about 67 nm and a narrow size distribution were obtained. Furthermore, the obtained results show the advantages of the meso‐OFR over a stirred tank batch reactor due to the production, about four times faster, of smaller and more uniform HAp nanoparticles. © 2013 American Institute of Chemical Engineers AIChE J , 59: 4483–4493, 2013