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Modeling of extraction behavior of docosahexaenoic acid ethyl ester by utilizing slug flow prepared by microreactor
Author(s) -
Kamio Eiji,
Seike Yu,
Yoshizawa Hidekazu,
Ono Tsutomu
Publication year - 2010
Publication title -
aiche journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.958
H-Index - 167
eISSN - 1547-5905
pISSN - 0001-1541
DOI - 10.1002/aic.12132
Subject(s) - extraction (chemistry) , microreactor , slug flow , chemistry , mass transfer , diffusion , aqueous solution , kinetic energy , docosahexaenoic acid , liquid–liquid extraction , chromatography , toluene , chemical engineering , analytical chemistry (journal) , flow (mathematics) , organic chemistry , thermodynamics , fatty acid , two phase flow , catalysis , polyunsaturated fatty acid , geometry , mathematics , physics , quantum mechanics , engineering
The liquid–liquid extraction dynamics of an ethyl ester of docosahexaenoic acid (DHA‐Et) with silver ion was investigated. The kinetic model was derived according to the following stepwise processes: Diffusion of DHA‐Et across the organic film, complex‐formation between DHA‐Et and silver ion at the interface, and diffusion of extracted complex across the aqueous film. The kinetic parameters for the complex‐formation reaction were determined from the investigation with the stirred transfer cell. With the proposed model and determined parameters, we predicted the uptakes of DHA‐Et for the extraction system utilizing a slug flow prepared by a microchip. The calculated uptakes showed good correlation to the experimental data. The theoretical investigation suggested that the fast equilibration realized for the slug flow extraction system was due to the large specific interfacial area of the slug caused by the presence of wall film and the thin liquid film caused by the internal circulation. © 2009 American Institute of Chemical Engineers AIChE J, 2010