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Workflow for managing impurities in an integrated crystallization process
Author(s) -
Cheng Yuen S.,
Lam Ka W.,
Ng Ka M.,
Wibowo Christianto
Publication year - 2010
Publication title -
aiche journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.958
H-Index - 167
eISSN - 1547-5905
pISSN - 0001-1541
DOI - 10.1002/aic.12027
Subject(s) - crystallization , workflow , impurity , process (computing) , process engineering , ascorbic acid , computer science , process development , materials science , chemical engineering , chemistry , engineering , database , organic chemistry , food science , operating system
A workflow consisting of experiments, modeling, and synthesis is presented for managing the impurity content in the product crystals of a crystallization process taking into consideration the entire train of crystallization and downstream processing steps. Experiments on solid–liquid equilibrium, impurity inclusion, washing, and deliquoring are designed in such a way that the experimental data or the model parameters derived from these data can be readily used for process design. Guidelines for experimental design and tradeoffs in process synthesis are discussed. The workflow is illustrated using the purification of Vitamin C (ascorbic acid) as a case study. © 2009 American Institute of Chemical Engineers AIChE J, 2010