Premium
Efficient separation of enantiomers by preferential crystallization in two coupled vessels
Author(s) -
Elsner Martin Peter,
Ziomek Grzegorz,
SeidelMorgenstern Andreas
Publication year - 2009
Publication title -
aiche journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.958
H-Index - 167
eISSN - 1547-5905
pISSN - 0001-1541
DOI - 10.1002/aic.11719
Subject(s) - crystallization , enantiomer , chemistry , work (physics) , chemical engineering , process (computing) , chromatography , materials science , crystallography , thermodynamics , stereochemistry , organic chemistry , computer science , engineering , physics , operating system
The focus of this work is to study the enantioseparation of conglomerate forming systems using an innovative configuration for preferential crystallization. Two batch crystallizers are coupled by an exchange of their liquid phases. In each vessel one of the two enantiomers is seeded initially and crystallizes subsequently. Compared with conventional single batch crystallization the exchange of the crystal free liquid phases between two crystallizers leads to an increase of the concentrations of the preferred enantiomers and therefore to an increase of the driving forces for the crystallization. This enhances the productivity of the process compared with the conventional operation. © 2009 American Institute of Chemical Engineers AIChE J, 2009