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Computer evaluation of hydrogel‐based systems for diabetes closed loop treatment
Author(s) -
SánchezChávez Irma Y.,
MartínezChapa Sergio O.,
Peppas Nicholas A.
Publication year - 2008
Publication title -
aiche journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.958
H-Index - 167
eISSN - 1547-5905
pISSN - 0001-1541
DOI - 10.1002/aic.11501
Subject(s) - self healing hydrogels , membrane , closed loop , glucose oxidase , cationic polymerization , biomedical engineering , basal insulin , computer science , swelling , materials science , chemistry , chemical engineering , nanotechnology , diabetes mellitus , engineering , polymer chemistry , control engineering , biosensor , type 2 diabetes , biochemistry , medicine , endocrinology
Hydrogels provide the multifunctionality of smart materials and the applicability to medical regulatory systems. Hydrogel membranes that incorporate glucose oxidase for the closed loop treatment of type 1 diabetes mellitus are characterized and modeled. The Sorensen compartmental model is extended to represent the treatment system of a diabetic patient. The performance of the system closed by a hydrogel‐based device is explored and compared to the dynamic behavior of a conventional scheme with an explicit controller element. Anionic and cationic hydrogels are discussed for insulin delivery application. Simulations demonstrate limitations in the range of swelling and contraction of hydrogels in a physiological environment due to the Donnan equilibrium effect. Results show the reduction of peak glucose levels and a basal insulin delivery from a hydrogel membrane system. The evaluation of ionic hydrogel membrane macrosystems prompts the consideration of detected pros and cons using different hydrogels, structures and scales. © 2008 American Institute of Chemical Engineers AIChE J, 2008