Open AccessSignificant impact of cachexia index on the outcomes after hepatic resection for colorectal liver metastases
Author(s) -
Tanji Yoshiaki,
Furukawa Kenei,
Haruki Koichiro,
Taniai Tomohiko,
Onda Shinji,
Tsunematsu Masashi,
Shirai Yoshihiro,
Yanagaki Mitsuru,
Igarashi Yosuke,
Ikegami Toru
Publication year - 2022
Publication title -
annals of gastroenterological surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.308
H-Index - 15
ISSN - 2475-0328
DOI - 10.1002/ags3.12578
Subject(s) - medicine , hazard ratio , gastroenterology , cachexia , multivariate analysis , confidence interval , neutrophil to lymphocyte ratio , lesion , retrospective cohort study , overall survival , surgery , cancer
The purpose of this study was to investigate the relation between preoperative cachexia index (CXI) and long‐term outcomes in patients with colorectal liver metastases (CRLM) after hepatic resection. Method In all,118 patients who underwent hepatic resection for CRLM were analyzed retrospectively. The relationship between CXI and the long‐term outcomes in patients after hepatic resection was investigated. CXI was calculated based on preoperative skeletal muscle index, serum albumin level, and neutrophil–lymphocyte ratio. Results The multivariate analysis showed that extrahepatic lesion (hazard ratio [HR] 2.86, 95% confidence interval [CI] 1.48–5.53, P < .01) and high CXI (HR 0.44, 95% CI 0.20–0.98, P = .04) were independent and significant predictors of disease‐free survival. Moreover, extrahepatic lesion (HR 2.32, 95% CI 1.03–5.22, P = .04), high CXI (HR 0.17, 95% CI 0.05–0.57, P < .01), and curability R 1 or 2 (HR 3.29, 95% CI 1.23–8.78, P = .02) were independent and significant predictors of overall survival. Conclusion CXI is a useful prognostic factor for disease‐free survival and overall survival after hepatic resection in CRLM patients.