Open AccessSignificance of intra/post‐operative prognostic scoring system in hepatectomy for colorectal liver metastases
Author(s) -
Furukawa Kenei,
Onda Shinji,
Yanagaki Mitsuru,
Taniai Tomohiko,
Hamura Ryoga,
Haruki Koichiro,
Shirai Yoshihiro,
Tsunematsu Masashi,
Sakamoto Taro,
Ikegami Toru
Publication year - 2022
Publication title -
annals of gastroenterological surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.308
H-Index - 15
ISSN - 2475-0328
DOI - 10.1002/ags3.12507
Subject(s) - medicine , multivariate analysis , hepatectomy , univariate analysis , gastroenterology , surgery , colorectal cancer , overall survival , resection , lesion , cancer
Aim The prognostic impact of postoperative systemic inflammatory response using an intra/post‐operative prognostic scoring system in patients with colorectal liver metastases (CRLM) after hepatic resection had never been investigated previously. Methods In total, 149 patients who underwent hepatic resection for CRLM were analyzed retrospectively. Intra/post‐operative prognostic scoring was performed using the postoperative modified Glasgow Prognostic Score (mGPS) at the first visit, after discharge, or a month after surgery during hospitalization. We investigated the association between clinicopathologic variables and disease‐free survival or overall survival by univariate and multivariate analyses. Results The median evaluation period of postoperative mGPS was 30 (26‐36) days after hepatectomy. Seventy‐one patients (48%) were classified as postoperative day 30 mGPS 1 or 2. In multivariate analysis, an extrahepatic lesion ( P = .02), multiple tumors ( P = .05), and postoperative day 30 mGPS 1 or 2 ( P < .01) were independent and significant predictors of disease‐free survival. Moreover, extrahepatic lesion ( P = .04), and postoperative day 30 mGPS 1 or 2 ( P = .02) were independent and significant predictors for overall survival. Patients with postoperative day 30 mGPS 1 or 2 had significantly more advanced tumors, more invasive surgery, and more chances of infectious postoperative complications than those with postoperative day 30 mGPS 0. Conclusion Postoperative systemic inflammatory response, as evidenced by intra/post‐operative prognostic scoring system using postoperative day 30 mGPS, was a strong predictor for outcomes in patients who underwent liver resection for CRLM.