Open AccessElevation of Mac‐2 binding protein glycosylation isomer after hepatectomy is associated with post‐hepatectomy liver failure, total Pringle time, and renal dysfunction
Author(s) -
Imai Daisuke,
Maeda Takashi,
Wang Huanlin,
Sanefuji Kensaku,
Kayashima Hiroto,
Yoshiya Shohei,
Takeishi Kazuki,
Itoh Shinji,
Harada Noboru,
Ikegami Toru,
Yoshizumi Tomoharu,
Mori Masaki
Publication year - 2019
Publication title -
annals of gastroenterological surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.308
H-Index - 15
ISSN - 2475-0328
DOI - 10.1002/ags3.12271
Subject(s) - hepatectomy , glycosylation , liver failure , medicine , hepatic dysfunction , chemistry , urology , surgery , biochemistry , resection
Background Mac‐2 binding protein glycosylation isomer (M2BPGi) is a novel serum glycomarker used to assess liver fibrosis. However, it has been reported that M2 BPG i is likely to reflect other factors not limited to liver fibrosis. Methods We retrospectively analyzed 79 patients with liver tumors who underwent liver resection. M2 BPG i was measured within 1 week before operation and almost 1 month after operation. We introduced a value termed the “ΔM2 BPG i ratio” (=M2 BPG i after operation /M2 BPG i before operation ), and analyzed factors that influenced the ΔM2 BPG i ratio. Results The median value of the ΔM2 BPG i ratio was 1.28 (range, 0.36‐5.68). In 64 patients (81.0%), the cutoff index values of M2 BPG i were elevated approximately 1 month after operation, especially in patients who experienced post‐hepatectomy liver failure (PHLF). Multiple linear regression showed total Pringle time, PHLF grade ≥B, and preoperative value of creatinine were significant predictors of the ΔM2 BPG i ratio. The mean values of the ΔM2 BPG i ratio were 1.37 ± 0.07, 1.52 ± 0.22, and 2.94 ± 0.30 for PHLF grade 0, grade A, and grade B, respectively, resulting in statistically significant differences by the Kruskal‐Wallis test ( P = 0.022). Conclusions Total Pringle time, PHLF grade ≥B, and preoperative creatinine significantly influenced the elevation of M2BPGi almost 1 month after liver resection. This study strongly affirms the previous suggestion that M2 BPG i is likely to reflect other factors not limited to liver fibrosis.